Table 1.
miRNA implicated in the diabetic animal model.
| Mature Sequence of miRNA | Species | Experimental Model | Expression | Number of Study |
References |
|---|---|---|---|---|---|
| hsa-let-7i-5p | Mouse | Db mice | Up | 1 | [26] |
| hsa-miR-129-1-3p | Mouse | Db mice | Down | 1 | [26] |
| hsa-miR-130a-3p | Mouse, cell | Db mice, HepG2 cells | Up | 1 | [27] |
| hsa-miR-133b | Rat | High-Fat Diet/Streptozotocin-Induced Diabetic Rat | Up | 1 | [28] |
| hsa-miR-134-5p | Mouse, cell | C57BL/KsJ db mice, Db/Db mice, podocytes | Up | 1 | [29] |
| hsa-miR-146a-5p | Mouse, cell | C57BL/6J, miR-146a−/− mice, Podocytes, HK-2 human kidney cells, Db mice, peritoneal macrophages | Up, Down | 3 | [30,31,32] |
| hsa-miR-148b-3p | Rat, cell | Proximal tubular cells | Down | 1 | [33] |
| hsa-miR-16-5p | Rat | Male Wistar rats | Up | 1 | [34] |
| hsa-miR-181a-5p | Rat, cell | HK-2 cells, Otsuka-Long-Evans-Tokushima-Fatty rats | Down | 1 | [35] |
| hsa-miR-192-5p | Mouse | Db mice, Ets-1–deficient mice | Up | 1 | [36] |
| hsa-miR-200c-3p | Mouse, cell | Db mice, M4200 cells | Down | 3 | [26,37,38] |
| hsa-miR-21-5p | Mouse, rat, cell | C57BI/6J mice, miR-21-KO mice, DBA/2J mice, Db mice, kk-ay mice, epithelial-to-mesenchymal, podocytes | Up, Down | 7 | [39,40,41,42,43,44,45] |
| hsa-miR-217-5p | Cell | Glomerular mesangial cells | Up | 1 | [46] |
| hsa-miR-218-5p | Mouse, cell | Db mice, podocytes | Up, Down | 2 | [26,47] |
| hsa-miR-23c | Rat, cell | HK-2 cells | Down | 1 | [48] |
| hsa-miR-26a-5p | Rat, cell | OLETF rats, NRK-52E cells, glomerular, mesangial cells, podocytes, proximal tubular epithelial cells | Up, Down | 2 | [49,50] |
| hsa-miR-29a-3p | Mouse, cell | Db mice, Smad3-knockout (KO) db mice, mouse embryonic fibroblasts, NRK52E cells, mesangial cells | Down | 2 | [51,52] |
| hsa-miR-29a-5p | Mouse | Male FVB mice | Down | 1 | [53] |
| hsa-miR-29c-3p | Mouse | Db mice | Down | 1 | [26] |
| hsa-miR-30a-5p | Rat | High-Fat Diet/Streptozotocin-Induced Diabetic Rat | Up | 1 | [28] |
| hsa-miR-335-5p | Mouse | Male C57BL/6J mice | Up | 1 | [54] |
| hsa-miR-33a-5p | Mouse, cell | Db mice, MMCs (CRL1927) and HEK293 cells | Down | 1 | [55] |
| hsa-miR-342-5p | Rat | High-Fat Diet/Streptozotocin-Induced Diabetic Rat | Up | 1 | [28] |
| hsa-miR-34a-5p | Mouse, cell | Db mice, mesangial cells, HK-2cells, podocytes | Down | 3 | [56,57,58] |
| hsa-miR-375-5p | Mouse | Male C57BL/6J mice | Up | 1 | [54] |
| hsa-miR-378d | Mouse | Db mice | Up | 1 | [26] |
| hsa-miR-451a | Mouse, rat | Db mice, male Wistar rats | Down | 2 | [34,59] |
| hsa-miR-7977 | Mouse | Db mice | Down | 1 | [26] |
| hsa-miR-92b-5p | Rat | Lean Zucker, obese Zucker rats | Down | 1 | [60] |
| hsa-miR-93-5p | Mouse, cell | Pod-iCreERT2 mice, podocytes | Down | 1 | [61] |
| hsa-miR-99b-5p | Mouse, rat, cell | Db mice, mesangial cells, proximal tubular epithelial cells | Down | 4 | [62,63,64,65] |
miRNAs are annotated as a mature sequence of miRNA identified from the miRbase database.