Table 2.
Presence of MRONJ and comorbidities in the articles included in this systematic review.
| Authors (Year) | MRONJ Reported Cases | Comorbidities | MRONJ Detection Method | Use of Antimicrobial Therapy |
|---|---|---|---|---|
| August et al. (2011) [35] | No cases were reported. | NDA | Not specific. | N/A |
| Bredell et al. (2017) [36] | 1 case (case 2). MRONJ stage 2 (poor healing after exploratory surgery). | NDA | Not specific. | N/A |
| Brown et al. (2008) [37] | No cases were reported. | NDA | Clinical and radiographic evaluation. | NDA |
| Carpenter et al. (2007) [38] | No cases were reported. | NDA | Not specific. | N/A |
| Chahine et al. (2008) [39] | No cases were reported. | NDA | Search in medical record and follow up control notes from dentist that treats patient. | Prophylactic antibiotic therapy was used in 12 patients. |
| Feehan et al. (2018) [40] | No cases were reported. | Psychiatric (n = 4), cardiovascular (n = 3), respiratory (n = 1), endocrinology (n = 1) ENT (n = 3), others (n = 4). | Not specific. | N/A |
| Goldsby et al. (2013) [41] | No cases were reported. | NDA | Not specific. | N/A |
| Idolazzi et al. (2017) [42] | No cases were reported. | NDA | Not specific. | N/A |
| Ierardo et al. (2017) [43] | No cases were reported. | NDA | Radiographic and clinical evaluation. | Amoxicillin 50 mg/kg 30–60 min before surgery. Clindamycin 20 mg/kg was used in allergy sufferers 30–60 min before surgery. |
| Johannesen et al. (2009) [44] | No cases were reported. | NDA | Not specific. | N/A |
| Kumar et al. (2016) [45] | No cases were reported. | NDA | Not specific. | N/A |
| Li et al. (2011) [46] | No cases were reported. | They do not present rickets, hyperparathyroidism, other hereditary or metabolic bone pathologies, history of treatment with bisphosphonates, abnormal renal function (exclusion criteria). | Not specific. | N/A |
| Lindahl et al. (2016) [47] | No cases were reported. | NDA | Not specific. | N/A |
| Maines et al. (2012) [48] | No cases were reported. | NDA | Clinical examination by dental surgeon. | NDA |
| Malmgren et al. (2008) [49] | No cases were reported. | Its absence is presumed due to the non-administration of steroids or cytostatics. | Clinical and radiographic reviews every 6 months by a dentist or doctor. Radiographic evaluation in two children younger than 3 years was omitted. | Penicillin for 7 days in one case to treat a postoperative infection, which healed without complications. |
| Milano et al. (2011) [50] | No cases were reported. | NDA | Clinical evaluation. | Ampicillin 50 mg/kg single dose prior to surgical procedure. |
| Moeini et al. (2013) [51] | 12 cases. | NDA | Clinical evaluation. | N/A |
| Naidu et al. (2014) [52] | No cases were reported. | NDA | Not specific. | N/A |
| Nasomyont et al. (2019) [53] | No cases were reported. | NDA | Not specific. | N/A |
| Ngan et al. (2013) [54] | No cases were reported. | NDA | Clinical evaluation 1st month and 3rd month. There were no signs of infection, exposed bone, or osteonecrosis. | Amoxicillin for 5 days. |
| Okawa et al. (2017) [55] | No cases were reported. | NDA | Not specific. | NDA |
| Piperno-Neumann et al. (2018) [56] | No cases were reported. | NDA | Not specific. | N/A |
| Putman et al. (2018) [57] | No cases were reported. | NDA | Not specific. | N/A |
| Schwartz et al. (2008) [58] | No cases were reported. | NDA | Clinical evaluation in some cases. | 13–15 patients (not specify more details). |
| Simm et al. (2011) [59] | No cases were reported. | NDA | Dental evaluation. | N/A |
| Tessaris et al. (2016) [60] | No cases were reported. | NDA | Clinical and imaging evaluation (orthopantomography and CTCB). | NDA |
| Uday et al. (2018) [61] | 1 case. MRONJ Stage 2 after extraction of a fractured molar. | NDA | Clinical evaluation. | Amoxicillin and metronidazole as a treatment for MRONJ. |
| Vuorimies et al. (2011) [62] | No cases were reported. | NDA | Not specific. | N/A |
| Wagner et al. (2011) [63] | No cases were reported. | NDA | Not specific. | N/A |
ENT: ear, nose, throat; NDA: no data available.