Table 3.
Distribution of data from patients undergoing invasive dental procedures and MRONJ report.
| Authors | Number of pts. | Avg. Age (Range) | Sex | Medication | Invasive Procedures | Time of Invasive Procedure (during tx./After tx./Unknown) | Duration of ART tx. Prior to the inVasive Procedure (Avg. in yr.) | Cumulative Dose Prior to the Invasive Procedure | Use of Antibiotic Therapy | Post-Operatory Follow-up Time (Range) in yr. | MRONJ Report |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Bredell et al. [36] | 1 | 18.00 | 1(F) | DS | Maxillary exploratory surgery. | 1/0/0 | 0.66 | NDA | NDA | NDA | |
| Brown et al. [37] | 11 | 6.61 (1.65 to 12.47) | NDA | PD and ZD | 20 primary teeth extractions, 4 permanent teeth surgical extractions included, 2 simple permanent teeth extractions, 1 canine surgical exposure included, 1 odontoma excision. | 28/0/0 | PD (n = 11): 3.50 ZD (n = 6): 1.20 |
PD: 1250 mg on avg. ZD: 11.1 mg on avg. |
NDA | NDA | 1 case (stage 2). |
| Chahine et al. [39] | 113 | 14.00 (2.00 to 30.00). (Data from only 66 patients). | 41 (M) 25 (F) (Data from only 66 patients). |
PD | 178 primary tooth extractions, 72 permanent teeth extractions (32 simple and 40 surgical). | 163/87/0 | 4.60 (Data from only 66 patients) |
40 mg/kg on avg. (Data from only 66 patients). |
Applied in 12 patients. (Data from only 66 patients). |
0.23 (0.00 to 3.75). Telephone follow-up: 2.48 (0.12 to 10.38) | None |
| Ierardo et al. [43] | 20 | NDA (8.00 to 14.00) |
12 (M) 8 (F) |
ND | 35 scaling (tart removal), 20 germenectomies, 15 primary tooth extractions, 5 canine extractions included, 8 frenilectomies, 3 ankylosed molar extractions. | 86 / 0 / 0 | NDA | NDA | Used with 2 patients. Amoxicillin 50 mg/kg 30–60 min before surgery. Clindamycin 20 mg/kg was used in allergy sufferers 30–60 min before surgery. | NDA (2 to 5) | None |
| Maines et al. [48] | 2 | NDA | NDA | ND | 2 pulpectomies. | 2/0/0 | NDA | NDA | NDA | NDA | None |
| Malmgren et al. [49] | 22 | 12.20 (3.40 to 31.90) | 10 (M) 12 (F) |
PD | 30 tooth extractions, 6 surgical extractions, 1 orthognathic surgery, 1 implant surgery, 1 endodontic treatment. | 33/6/0 | 3.60 | NDA | NDA | 3.10 (0.90 to 8.00) | None |
| Milano et al. [50] | 1 | 4.66 | 1 (M) | PD | 5 primary tooth extractions. | 5/0/0 | NDA | NDA | Not applied. | 2.75 | None |
| Ngan et al. [54] | 1 | 12.00 | 1 (F) | PD | 6 primary tooth extractions. | 6 / 0 / 0 | NDA | NDA | Amoxicillin for 5 days. | 0.25 | None |
| Okawa et al. [55] | 31 | NDA | NDA | NDA | 67 primary tooth extractions. | 67 / 0 / 0 | NDA | NDA | NDA | NDA | None |
| Schwartz et al. [58] | 13 | NDA (2.00 to 16.00) |
NDA | NDA | 50 extractions of primary teeth and 10 of permanent teeth. | 39 / 11 / 10 | NDA | NDA | Used in 12 patients, not used with 2 and there is no data from 1 patient. | NDA | None |
| Uday et al. [61] | 1 | 19.00 | 1 (M) | DS | 1 permanent tooth extraction. | 1/0/0 | NDA | 98 mg/kg | NDA | NDA | 1 case (stage 2). |
ART: antiresorptive; avg.: average; DS: denosumab; ND: neridronate; PD: pamidronate; pts.: patient(s); tx.: treatment; yr.: year(s); ZD: zoledronate.