Table 5.
Investigated hsa-miRs expression level in HCC study participants’ (n = 39) according to AFP-positivity or negativity.
| AFP -/+ HCC, n | |||
|---|---|---|---|
| Characteristics (unit) | AFP-ve HCC, 12 | AFP + ve HCC, 27 | p Value |
|
hsa-miR-21-5p-fold changes Min–Max median (inter-quartiles) |
1.92–69.5 14.8 (3.0–34.8) |
3.29–407.31 32.6 (21.3–116.9) |
0.015 * |
|
hsa-miR-155-5p-fold changes Min–Max median (inter-quartiles) |
0.17–247.3 1.7 (0.46–6.6) |
0.80–324.03 3.8 (1.9–11.2) |
NS |
|
hsa-miR-192-5p-fold changes Min–Max median (inter-quartiles) |
0.14–23.2 0.97 (0.45–3.5) |
0.09–3.86 0.90 (0.36–1.4) |
NS |
|
hsa-miR-199a-5p fold changes Min–Max median (inter-quartiles) |
0.01–2.38 0.16 (0.035–0.38) |
0.00–5.39 0.23 (0.04 –0.63) |
NS |
|
hsa-miR-21-5p/hsa-miR-199a-5p Min–Max median (inter-quartiles) |
12.13–8364.1 52.7 (16.8–311.3) |
1.06–121,449.75 87.4 (32.2–3468.3) |
NS |
|
hsa-miR-155-5p/hsa-miR-199a-5p Min–Max median (inter-quartiles) |
2.7–29,737.5 12.3 (3.8–29.9) |
0.15–41,764.80 17.4 (6.9–207.9) |
NS |
Data are median (inter quartile range (1st–3rd quartile)), statistics were computed using SPSS software. * Statistical significance p-value < 0.05; NS, non-significant for comparison of AFP–HCC and AFP+HCC sub-classification. HCC, hepatocellular carcinoma; LC, liver cirrhosis; AFP, alpha fetoprotein.