Table 5.

Docking scores and distance from the zinc atom of the examined compounds and the co-crystallized inhibitors at the binding site of the hCA-II and hCA-XII enzymes.

Phenolic Compounds	hCA-II		hCA-XII
	Docking Score (kcal · mol−1)	Distance Zn2+ (Å)	Docking Score (kcal · mol−1)	Distance Zn2+ (Å)
2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid	−4.86	1.76	1 NT	NT
2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide	NT	NT	−3.67	1.76
Apigenin	−5.70	2.23	−5.64	2.01
Caffeic acid	−4.46	2.05	−5.26	2.12
Chlorogenic acid	−5.73	2.06	−5.95	2.17
Kaempferol	−5.31	2.06	−4.90	2.04
Naringenin	−5.32	2.05	−5.02	2.00
Quercetin	−5.13	2.23	−5.29	2.17
Rosmarinic acid	−4.72	2.05	−5.73	2.12
Syringic acid	−5.48	2.05	−4.89	2.15

¹ NT: Not Tested.