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. 2023 Feb 7;15(2):550. doi: 10.3390/pharmaceutics15020550

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) IOP decrease in normotensive rabbits after single instillation of enalaprilat-loaded hybrid particles (red), SOD1-loaded hybrid particles (blue) and SOD1/enalaprilat co-loaded hybrid particles (green). (b) Comparison of IOP decrease in normotensive rabbits an hour after single instillation of enalaprilat-loaded hybrid particles, SOD1-loaded hybrid particles, and SOD1/enalaprilat co-loaded hybrid particles. The mean is marked with a dot. Value interval 25–75% is indicated by the grey area. * p< 0.05, ** p< 0.01.