Table 1.
Summary of launched DNA topoisomerase inhibitors.
| Generic Name | Brand Name | Company | Approval | CAS Number | Clinical Indications | Molecular Mechanism |
|---|---|---|---|---|---|---|
| Prulifloxacin (1) | Pruvel | Nippon Shinyaku | 2004 | 123447-62-1 | Bronchitis Respiratory tract infections Gastroenteritis | DNA gyrase inhibitor |
| Sitafloxacin hydrate (2) | Gracevit | Daiichi Pharmaceutical | 2008 | 163253-36-9 | Gram-negative bacterial infection Pneumonia | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Besifloxacin hydrochloride (3) | Besivance | Bausch & Lomb | 2009 | 141388-76-3 | Ocular bacterial infection | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Nemonoxacin (4) | Taigexyn | Procter & Gamble | 2016 | 378746-64-6 | Diabetic complications Pneumonia Gram-positive bacterial infection |
DNA topoisomerase IV inhibitor |
| Pazufloxacin mesylate (5) | Pasil | FUJIFILM Toyama Chemical | 2014 | 127046-45-1 | Conjunctivitis, otitis media Pneumonia |
DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Gemifloxacin mesylate (6) | Factive | LG Chem | 2003 | 210353-56-3 | Acute rhinosinusitis Gram-negative bacterial infection Pneumonia |
DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Garenoxacin mesylate (7) | Geninax | Astellas & Taisho Toyama | 2007 | 223652-81-1 | Respiratory tract infections Pneumonia | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Zabofloxacin hydrochloride (8) | Zabolante | Dong Wha Pharmaceutical | 2015 | 219680-11-2 | Bronchitis Gram-positive bacterial infection Pneumonia |
DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Ozenoxacin (9) | Ozanex | Medimetriks Pharmaceutical | 2017 | 245765-41-7 | Acne Impetigo |
DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Delafloxacin meglumine (10) | Baxdela | Rib-X Pharmaceutical | 2017 | 352458-37-8 | Gonorrhea Acute bacterial skin and skin structure infections |
DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Levonadifloxacin arginine salt (11) | Emrok | Wockhardt | 2019 | 371246-52-5 | Acute bacterial skin and skin structure infections | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Alalevonadifloxacin mesylate (12) | Emrok O | Wockhardt | 2019 | 306303-00-4 | Acute bacterial skin and skin structure infections | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Lascufloxacin hydrochloride (13) | Lasvic | Kyorin | 2019 | 848416-07-9 | Pneumonia | DNA gyrase Inhibitor, DNA topoisomerase IV inhibitor |
| Finafloxacin (14) | Xtoro | MerLion Pharmaceutical | 2014 | 209342-40-5 | Acute otitis externa | DNA gyrase inhibitor, DNA topoisomerase IV inhibitor |
| Antofloxacin (15) | Youpeng | Anhui Global Pharmaceutical | 2009 | 119354-43-7 | BronchitisAcute pyelonephritis |
DNA gyrase inhibitor |
| Balofloxacin (16) | Qroxin | Roche | 2003 | 127294-70-6 | Urethritis Urinary tract infection |
DNA gyrase inhibitor |