Figure 2.

The most differentially expressed metabolites in participants with and without FIB-4 ≥ 1.45. Figure 2 displays metabolites that differed significantly in participants with and without FIB-4 ≥ 1.45 determined by p < 0.05 in Wilcoxon test. FIB-4 score ≥ 1.45 (“high” FIB-4 label) was defined as “unable to exclude advanced liver fibrosis/cirrhosis”. (A) Methylhistidine, beta-alanine, and histidine metabolism; (B) niacin metabolism and biomarker for consumption of coffee, legumes and soy products; (C) biomarker of caffeine consumption; (D) methyl-branched fatty acids involved in lipid transport and metabolism; (E) a crystalline acid obtained from cinchona bark, coffee beans, carrot leaves, apples, peaches, vegetables, etc., that is implicated in the perceived acidity of coffee; (F) the product of the metabolism of methylxanthines (caffeine, theophylline, and theobromine). Abbreviations: FIB-4, Fibrosis-4 Index.