Table 4.
Baseline characteristics of an example cohort of MS patients in MSDS-AOK PLUS.
| Characteristic | MS Cohort (N = 186) |
Data Source |
|---|---|---|
| Female, n (%) | 142 (76.34) | AOK PLUS |
| Age, years | AOK PLUS | |
| Mean (SD) | 49.14 (11.54) | |
| Median (Range) | 50.03 (22.01–79.05) | |
| Time since first diagnosis a, years | MSDS3D | |
| Mean (SD) | 12.07 (8.23) | |
| Median (Range) | 11.01 (0.67–44.03) | |
| MS subtype b, n (%) | MSDS3D | |
| First manifestation/CIS | 3 (1.61) | |
| RRMS | 144 (77.42) | |
| PPMS | 7 (3.76) | |
| SPMS | 18 (9.68) | |
| Not specified | 14 (7.53) | |
| Charlson Comorbidity Index (CCI) c | AOK PLUS | |
| 0 | 117 (62.90) | |
| 1–2 | 47 (25.26) | |
| 3–4 | 16 (8.60) | |
| ≥5 | 6 (3.23) | |
| EDSS | MSDS3D | |
| Mean (SD) | 3.35 (1.76) | |
| Median (Range) | 3 (1–8) | |
| EDSS distribution, n (%) | MSDS3D | |
| 1–1.5 | 33 (17.74) | |
| 2–2.5 | 51 (27.42) | |
| 3–3.5 | 30 (16.1) | |
| 4–4.5 | 22 (11.83) | |
| 5–5.5 | 2 (1.08) | |
| 6–6.5 | 26 (13.98) | |
| 7–7.5 | 6 (3.23) | |
| ≥8 | 1 (0.54) | |
| Not assessed | 15 (8.06) | |
| Comorbidities at baseline, n (%) | AOK PLUS | |
| Diabetes mellitus | 18 (9.68) | |
| Cardiovascular disease | 21 (11.29) | |
| Hypertension | 62 (33.33) | |
| Obesity | 18 (9.68) | |
| Depression & Anxiety | 61 (32.80) | |
a If missing (n = 15), date of first symptom was used, otherwise excluded; b MS subtype recording closest to the index date; c components to calculate CCI can be found in Table S1. Abbreviations: CIS, clinically isolated syndrome; EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; PPMS, primary progressive multiple sclerosis; RRMS, relapsing-remitting multiple sclerosis; SD, standard deviation; SPMS, secondary progressive multiple sclerosis.