. 2023 Feb 20;24(4):4193. doi: 10.3390/ijms24044193

Table 1.

Signaling pathways of prostanoids.

Prostanoid	Receptor	G-Protein	Signaling Pathway
PGD2	DP1	G_αs	AC and PKA activation—cAMP increase
	CRTH2	G_αi	cAMP decrease—Ca²⁺ increase
PGF2α	FP	G_αq	IP3 and Ca²⁺ increase
		G_α12/13	Rho activation
PGE2	EP1	G_αq	IP3 and Ca²⁺ increase
	EP2	G_αs	AC and PKA activation—cAMP increase
	EP3	G_αi or G_α12	Ca²⁺ increase—Rho activation
	EP4	G_αs	AC and PKA activation—cAMP increase
TxA2	TPα-TPβ	G_αq	IP3 and Ca²⁺ increase
		G_α12/13	Rho activation
PGI2	IP	G_αs	AC and PKA activation—cAMP increase

Note. AC: adenylyl cyclase. cAMP: cyclic adenosine monophosphate. IP3: inositol trisphosphate. PKA: protein kinase A/cAMP-dependent protein kinase.