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. 2023 Feb 2;15(2):501. doi: 10.3390/pharmaceutics15020501

Table 1.

Surfactants mostly used in drug delivery.

Surfactant Category HLB Groups
Span 85 Non-ionic 1.8 Hydrophobic (oil soluble)
Span 65 Non-ionic 2 Hydrophobic (oil soluble)
Span 80 Non-ionic 4.3 Hydrophobic (oil soluble)
Span 60 Non-ionic 4.7 Hydrophobic (oil soluble)
Span 40 Non-ionic 6.7 Hydrophobic (oil soluble)
Span 20 Non-ionic 8.6 Water Dispersable
Brij 30 Non-ionic 9.5 Water Dispersable
Tween 61 Non-ionic 9.6 Water Dispersable
Tween 81 Non-ionic 10 Water Dispersable
Tween 65 Non-ionic 10.5 Water Dispersable
Tween 85 Non-ionic 11 Water Dispersable
PEG 400 monooleate Non-ionic 11.4 Water Dispersable
PEG 400 monostearate Non-ionic 11.6 Water Dispersable
Brij 97 Non-ionic 12.5 Hydrophilic (water soluble)
Lipocol C-10 Non-ionic 12.9 Hydrophilic (water soluble)
Tween 21 Non-ionic 13.3 Hydrophilic (water soluble)
Tween 60 Non-ionic 14.9 Hydrophilic (water soluble)
Tween 80 Non-ionic 14.9 Hydrophilic (water soluble)
Tween 40 Non-ionic 15.6 Hydrophilic (water soluble)
Tween 20 Non-ionic 16.7 Hydrophilic (water soluble)
Brij 35 Non-ionic 16.9 Hydrophilic (water soluble)
Solutol SH-15 Non-ionic 15.2 Hydrophilic (water soluble)