Table 3.

Animal models for development of EBOV Vaccines [+++: High; ++: Moderate; +: Low].

Ebola Virus	Animal Models	Route of Inoculation	Display of Human Symptoms	Cost of Handling	Ease of Handling	Applications
Wild Type EBOV	Non-human primate	Multiple routes of inoculation	+++	+++	+++	Confirmatory model
	Ferret	Intranasal	++	++	++	Not well established
	Humanized mouse	Intraperitoneal	++	+++	+	Not well established
Guinea Pig adapted EBOV	Guinea Pig	Intraperitoneal, Subcutaneous, Aerosol	+	+	+	Screening model
Mouse adapted EBOV	Laboratory mouse	Intraperitoneal, Intranasal, Aerosol	+	+	+	Screening model
	Hamster	Intraperitoneal	++	+	+	Screening model