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. 2023 Feb 11;28(4):1728. doi: 10.3390/molecules28041728

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of rhamnose, rutinose, hesperidin, and hesperetin on MMP-1, MMP-2, and collagen 1 production. MMP-1 (A), MMP-2 (C), and collagen 1 (E) production in young NHDFs, that were cultivated in low glucose medium or high glucose medium or medium supplemented with AGEs and the effects of rhamnose, rutinose, hesperidin, and hesperetin on MMP-1 (B), MMP-2 (D) and collagen 1 (F) production in physiologically aged NHDFs cultivated in low-glucose medium, high-glucose medium and medium supplemented with AGEs. Untreated NHDFs cultured in the respective media were used as controls. A number of measurements: n = 6. * p < 0.05 were considered significant compared to the control. (One-way ANOVA; Dunnett’s multiple comparisons tests were performed using GraphPad Prism).