Fig. 4.

Associations of regional glycolysis (GI) with aging and AD. The associations of aging and symptomatic AD with GI were explored at a regional level. Regression models were constructed for each independent gray matter region relating GI to age, sex, and AD and subject as a random effect. As this was an exploratory non-quantitative analysis, only regions showing a significant decrease (defined as t-score < −1.96, uncorrected) in GI are shown here, noting that both age and AD are known to be associated with lower whole brain AG (17, 19, 20). AD was associated with decreases in the precuneus, prefrontal, lateral parietal, and temporal regions. Aging was associated with relative decreases primarily in medial frontal and dorsal frontal and parietal areas, consistent with that reported previously. (In the upper right graph, blue and red dots reflect individuals without and with symptomatic Alzheimer disease, respectively. In the lower right graph, blue and red dots reflect individuals without and with brain amyloid positivity, respectively.)