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. 2023 Feb 17;15(2):692. doi: 10.3390/pharmaceutics15020692

Figure 8.

Figure 8

Prenatal THC exposure (2 mg/kg) alters the mRNA relative expression levels of the effectors of excitatory and ECS-driven downstream signalling in adolescent rats. Prenatal THC exposure (a) increased the expression levels of the NMDAR NR1 subunit and decreased (b) the levels of NR2A and (c) PSD95 in the hippocampus of the adolescent male rat offspring. (d) pTHC induced an increase in mGluR5, as well as (e) its scaffolding partner Homer1 isoform in the hippocampus of the adolescent progeny. Lastly, (f) CB1R and (g) HINT1 were increased by pTHC in the hippocampus of the adolescent male offspring. Data are shown as the mean ± SEM. * p < 0.05; ** p < 0.01; **** p < 0.0001; CTRL = male rat offspring prenatally exposed to Veh; pTHC = male rat offspring prenatally exposed to THC.