Figure 1.

Genetic modifications of phage capsids. (A) Single amino acids in phage capsids can be substituted to alter the number and type of functional groups accessible for downstream chemical modification. (B) Peptide motifs recognized by specific enzymes can be incorporated into phage capsids for downstream enzymatic modification or the controlled release of contents. (C) Recombinant capsid decoration proteins can be synthesized separately from the phage and assembled to the capsid in vitro, allowing for large complex proteins to be displayed. This figure is reproduced from [14] (© 2021 American Chemical Society).