Table 5.
Upstream regulator of DEGs in oocytes cultured on gel culture systems.
| Upstream | Molecular | Predicted | Activation | p Value |
|---|---|---|---|---|
| Regulator | Type | Activation State | Z-Score | of Overlap |
| MYC | transcription regulator | Activated | 7.392 | 3.42 × 10−21 |
| MYCN | transcription regulator | Activated | 3 | 9.15 × 10−21 |
| beta-estradiol | chemical-endogenous mammalian | Activated | 3.75 | 1.14 × 10−20 |
| torin1 | chemical reagent | Inhibited | −4.543 | 1.32 × 10−19 |
| Lh | complex | Activated | 4.001 | 3.15 × 10−19 |
| TP53 | transcription regulator | 1.571 | 3.73 × 10−19 | |
| LARP1 | translation regulator | Inhibited | −5.743 | 2.63 × 10−18 |
| APP | other | 0.412 | 3.84 × 10−16 | |
| CTNNB1 | transcription regulator | 1.635 | 1.24 × 10−15 | |
| TGFB1 | growth factor | Activated | 2.748 | 1.61 × 10−14 |
| MAPT | other | 0 | 1.98 × 10−14 | |
| RICTOR | other | Inhibited | −6.308 | 5.72 × 10−14 |
| ESR1 | ligand-dependent nuclear receptor | Activated | 3.228 | 5.94 × 10−13 |
| ST1926 | chemical drug | Inhibited | −5.492 | 1.22 × 10−12 |
| tretinoin | chemical-endogenous mammalian | −0.169 | 2 × 10−12 | |
| acyline | biologic drug | 4.67 × 10−12 | ||
| ESR2 | ligand-dependent nuclear receptor | Activated | 2.958 | 5.68 × 10−12 |
| MLXIPL | transcription regulator | Activated | 5.444 | 5.69 × 10−12 |
| dihydrotestosterone | chemical-endogenous mammalian | Activated | 2.984 | 3.36 × 10−11 |
| decitabine | chemical drug | 1.223 | 4.75 × 10−11 |
DEGs: differentially expressed genes. Activated: activated upstream regulator causing the differential expression of genes in the same direction. Inhibited: Inhibited upstream regulator causing the differentially expressed genes in the opposite direction.