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. 2023 Feb 6;120(7):e2215308120. doi: 10.1073/pnas.2215308120

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Copyright © 2023 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — ADNMs Encapsulate the Anticancer Drug and Induce Tumor-Assisted Drug Delivery via EV-Mediated Intercellular Transport. The amphiphilic dendrimer (AD) encapsulates the anticancer drug and forms nanomicelles (ADNMs) which reach the tumor lesion via the EPR effect. There they induce in situ tumor-assisted drug delivery for deep tumor penetration via EV-mediated intercellular transport. This EV-mediated delivery process involves: 1) internalization of ADNMs inside cells within the tumor tissue; 2) repackaging of ADNM payload into EVs; 3) intercellular transport of the generated EVs; 4) internalization of the generated EVs by the recipient cell.