Table 2.
Enzymatically derived ADSC-SVF human tendinopathy and tendon injury.
| Authors | Injury | ADSC-SVF Provenience | ADSC-SVF Delivery | Investigation | Outcomes |
|---|---|---|---|---|---|
| Jo et al. [49] | Partial thickness Rotator cuff tear | Autologous from abdominal area | Intralesional-injection | Clinical (SPADI score, CONSTANT score, VAS) Radiological (MRI), Arthroscopic |
Significantly alleviated shoulder pain with more than 70% reduction from the baseline in the high-dose group. At MRI the bursal-side defect significantly decreased by 90% in the high-dose group . Arthroscopic examination volume of the articular- and bursal- side defects decreased by 83% and 90%. |
| Kim et al. [50] | Partial thickness Rotator cuff tear | Autologous, derived from buttocks | ADSC loaded in fibrin glue was injected compared to standard suture | Clinical (VAS, ROM, CONSTANT score, UCLA score) Radiological (MRI) | No clinical differences. At MRI, improved structural outcomes, low retear rate |
| Hurd et al. [51] | Partial thickness Rotator cuff tear | Autologous, derived from either the periumbilical abdominal area, bilateral flanks, or medial thigh fat | Intralesional-injection | Clinical (ASES score, SF-36) | Significantly higher ASES score |
| Freitag et al. [52] | Common extensor tendon chronic tendinopathy | Autologous abdominal fat | Intralesional injection enriched with PRP | Clinical (NPRT, PRTE) Radiological (US, MRI) |
Significant improvements of clinical score and tendon structure |
| Khouri et al. [53] | Chronic lateral elbow tendinopathy | Autologous, derived from periumbilical zone | Percutaneous injection to the affected elbow | Clinical (VAS, qDASH) Radiological (MRI) |
Improved VAS scores for maximum pain score, QuickDASH -Compulsory score, QuickDASH-Sport score, MRI score for tendinopathy. |
| Lee et al. [54] | Lateral epicondylosis | Allogenic | Intratendinous injection with fibrin glue | Clinical (VAS, MEPI score) Radiological (US) |
Safe and improved elbow pain VAS, performance MEPI score, and structural defects |
| Khouri et al. [55] | Patellar tendinopathy | Autologous, derived from periumbilical zone | Percutaneous injection to the affected tendon | Clinical (VAS, Visa-P) Radiological (MRI) |
VAS and Visa-P score improved significantly. MRI revealed significantive improvement for tendon thickness, and tear length, width and thickness compared to baseline. |
ADSC (Adipose-Derived Stem Cell); SVF (Stromal Vascular Fraction); VAS (Visual Analogue Scale); MRI (Magnetic Resonance Imaging); Shoulder Pain and Disability Index (SPADI); University of California at Los Angeles—Activity (UCLA); American Shoulder and Elbow Surgeons (ASES); 36-Item Short Form Health Survey (SF-36); Numeric Pain Rating Scale (NPRT); Patient-Rated Tennis Elbow Evaluation (PRTE); Mayo elbow performance index (MEPI); Victorian Institute Sport Assessment-Patellar score (VISA-p).