Table 4.

Biomaterials and enzymatical/mechanical derived ADSC-SVF in vivo tendinopathy and tendon injury.

Authors	Injury (Animal)	Biomaterial	Treatment	ADSC-SVF Provenience	Investigation	Outcomes
Lipner et al. [64]	Rotator Cuff tears (Sprague Dawley rats)	Nanofibrous poly lactic co-glycolic acid scaffold	Group 1: tendon suture Group 2: tendon suture + acellular scaffold Group 3: tendon suture + ADSC scaffold Group 4: tendon suture + ADSC + BMP2 scaffold	Allogenic subcutaneous adipose tissue mice	Histological, bone morphology, biomechanical outcomes	The acellular scaffold showed a delayed healing response. Cellular + BMP2 scaffold showed decreased mechanical properties. No difference in bone morphology.
Chiou et al. [65]	Achilles tendon midsubstance defect (Wistar rats)	Tendon hydrogel scaffold	Group 1: saline control Group 2: tendon hydrogel Group 3: tendon hydrogel scaffold + PRP Group 4: tendon hydrogel scaffold + ADSC + PRP	Allogenic subcutaneous adipose tissue mice	Histological, Biomechanical analysis	Group 4 higher fibres organization. No biomechanical differences
Deng et al. [66]	Achilles’tendon defect (new zeland rabbits)	polyglycolic acid (PGA)+ PLA (polylactic acid)	Group 1: scaffold Group 2: scaffold + ADSC	Autologous, derived from nuchal side	Gross view, Histological Biomechanical analysis	Significant difference in mechanical strength in group 2, improved histological score.
Franklin et al. [67]	Achilles’tendon defect and rotator cuff chronic tendinopahty (Sprague Dawley rat)	Human decellularized flexor tendon hydrogel (tHG)	Group 1: saline Group 2: tHG Group 3: tHG + ADSC Group 4: tHg + FB Group5	In commerce	Flow citometry	Enhance homing of adsc cells administred ev.