. 2023 Feb 15;24(4):3903. doi: 10.3390/ijms24043903

Table 1.

IC₅₀ values (μM) from the dose-response assay of compounds 1a–1c and 2a–2h and the reference compound cisplatin in the A549, Bel-7402, Eca-109, HeLa and MCF-7 cell lines, after an incubation time of 48 h.

Compounds	A549		Bel-7402		Eca-109		HeLa		MCF-7
Compounds	IC₅₀ (μmol/L)	95% Confidence Intervals (μmol/L)	IC₅₀ (μmol/L)	95% Confidence Intervals (μmol/L)	IC₅₀ (μmol/L)	95% Confidence Intervals (μmol/L)	IC₅₀ (μmol/L)	95% Confidence Intervals (μmol/L)	IC₅₀ (μmol/L)	95% Confidence Intervals (μmol/L)
1a	2.858	2.142–3.813	2.667	0.455–0.718	3.115	2.575–3.769	7.249	6.118–8.589	1.229	0.980–1.540
1b	3.052	1.628–5.724	3.631	0.434–0.650	2.927	2.222–3.857	4.566	3.857–5.406	1.594	1.244–2.042
1c	2.811	2.034–3.883	2.751	0.308–0.450	2.196	1.818–2.652	2.935	1.765–4.883	0.850	0.671–1.077
2a	0.567	0.398–0.808	2.088	1.329–1.590	1.153	0.714–1.863	1.486	1.086–2.031	0.284	0.227–0.355
2b	0.754	0.519–1.096	0.730	0.616–0.796	0.579	0.486–0.688	1.583	1.085–2.310	0.525	0.399–0.691
2c	0.409	0.242–0.692	1.510	1.043–1.227	0.614	0.488–0.774	1.160	0.969–1.389	0.249	0.207–0.301
2d	0.281	0.217–0.364	1.382	0.304–0.471	0.645	0.502–0.829	0.356	0.280–0.452	0.819	0.583–1.151
2e	0.334	0.287–0.390	1.720	0.656–0.876	2.690	2.452–2.950	6.047	5.304–6.894	1.610	1.240–2.090
2f	0.723	0.538–0.970	1.011	0.441–0.605	0.886	0.717–1.094	2.889	1.815–4.600	0.501	0.360–0.698
2g	0.453	0.313–0.655	0.626	0.616–0.796	0.514	0.414–0.638	0.412	0.266–0.639	0.304	0.249–0.372
2h	0.626	0.455–0.862	0.523	1.043–1.227	0.868	0.677–1.111	2.648	1.683–4.167	0.379	0.317–0.454
Cisplatin	4.832	3.501–6.669	19.34	16.27–22.98	7.594	5.879–9.809	20.30	17.87–23.06	19.00	16.19–22.30