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. 2023 Feb 16;24(4):3992. doi: 10.3390/ijms24043992

Figure 1.

Figure 1

Conditions of heat stroke in ICR mice and the survival rate during heat exposure. (a) During heat exposure, WBGT (°C), ambient temperatures (ATs) (°C), and relative humidity (RH) (%) were measured with a digital thermo-hygrometer. The measurements were repeated four times and expressed as the mean ± SD. The WBGT (AT and RH) before heat exposure was 37.3 ± 0.0 °C (34.3 ± 0.0 °C and 99.9 ± 0.0%). It reached 42.0 ± 0.1 °C (38.0 ± 0.0 °C and 99.9 ± 0.0%) at 150 min. (b) The survival rate (%) of the wild-type (WT) and PACAP KO (KO) mice under heat exposure. WT (red line) and PACAP KO (blue line) mice (n = 10 each) were exposed to heat exposure for 150 min, and the survival time was observed. The survival rates at 150 min were 20.0% and 80.0% in the WT and PACAP KO groups, respectively (p < 0.05, by Kaplan–Meier survival analysis).