Table 1.
Baseline characteristics, clinical presentation and outcomes of patients with catheter-related bloodstream infection according to the underlying disease.
| Characteristic | Hematological Malignancies N = 369 (%) |
Solid Tumors N = 98 (%) |
Total N = 467 (%) |
p Value |
|---|---|---|---|---|
| Age (years, mean, SD) | 53.1 (15) | 55.5 (13.3) | ||
| Male sex | 225 (61.1) | 52 (53.1) | 277 (59.4) | 0.092 |
|
Hematological malignancies Acute leukemia Lymphoma Multiple myeloma Myelodysplastic syndrome Aplastic anemia Chronic myeloid leukemia Other 1 Hematopoietic stem cell transplant |
207 (56) 84 (22.8) 49 (13.3) 8 (2.17) 8 (2.17) 8 (2.17) 5 (1.35) 142 (38.5) |
|||
|
Solid tumors Breast cancer Colorectal cancer Head and Neck cancer Gynecological cancer Lung cancer Hepatobilliary tumor Other 2 |
24 (24.4) 23 (23.4) 11 (11.2) 10 (10.2) 9 (9.1) 5 (5.1) 16 (16.3) |
|||
|
Comorbidities Diabetes mellitus Chronic obstructive pulmonary disease Chronic heart disease Chronic renal disease Chronic liver disease |
92 (25) 38 (10.3) 21 (5.7) 18 (4.9) 11 (3) 8 (2.2) |
36 (36.7) 14 (14.3) 3 (3.1) 6 (6.1) 3 (3.1) 6 (6.1) |
128 (27.4) 52 (11.1) 24 (5.1) 24 (5.1) 14 (3) 14 (3) |
0.020 0.265 0.295 0.620 1.00 0.086 |
|
Immunosuppressive therapy Previous chemotherapy (1 month) Previous corticosteroids |
280 (76) 100 (27.1) |
71 (72.4) 35 (36.1) |
351 (75.2) 135 (29) |
0.485 0.083 |
| Neutropenia < 500cells/mm3 | 212 (57.6) | 11 (11.2) | 223 (48) | <0.001 |
| High-risk MASCC index score | 64 (28.7) | 3 (25) | 67 (28.5) | 1.00 |
| Parenteral nutrition | 26 (7) | 16 (16.3) | 42 (9) | 0.004 |
| Previous antibiotic therapy (1 month) | 196 (53.1) | 39 (39.8) | 235 (50.3) | 0.019 |
| Nosocomial acquisition | 290 (78.6) | 49 (50) | 339 (72.6) | <0.001 |
|
Type of catheter Peripheral PICC Central venous catheter Port reservoir |
37 (10) 21 (5.7) 306 (82.9) 4 (1.1) |
23 (23.5) 12 (12.2) 18 (18.4) 44 (45) |
60 (12.9) 33 (7.1) 324 (69.4) 48 (10.3) |
0.001 0.024 <0.001 <0.001 |
|
Etiology of CRBSI Gram-positive Gram-negative Fungi MDRGNB |
332 (90) 31 (8.7) 6 (1.6) 11 (3) |
75 (76.5) 18 (18.4) 5 (5.1) 6 (6.1) |
407 (87.2) 49 (10.5) 11 (2.36) 17 (3.6) |
<0.001 0.004 0.058 0.141 |
| Septic shock at presentation | 18 (4.9) | 6 (6.1) | 24 (5.1) | 0.620 |
| Inadequate empirical antibiotic therapy | 182 (49.6) | 48 (49) | 230 (49.5) | 0.914 |
| Catheter removal | 289 (78.5) | 89 (91.8) | 378 (81.3) | 0.003 |
| Intensive care unit admission | 20 (5.4) | 3 (3.1) | 23 (4.9) | 0.438 |
|
Case-fatality rates Overall 30-days 7-days 48-h |
46 (12.5) 18 (4.9) 7 (1.9) |
20 (21.5) 6 (6.2) 1 (1) |
66 (14.3) 24 (5.2) 8 (1.7) |
0.027 0.608 1.00 |
Other 1: Chronic myelomonocytic leukemia (3), Chronic Lymphatic Leukemia (2). Other 2: Urinary tract (4), melanoma (3), timoma (3), esophageal cancer (2), sarcoma (2), central nervous system (2). MASCC: Multinational Association of Supportive Care in Cancer. CRBSI: catheter-related bloodstream infection. PICC: peripherally-inserted central catheter. MDRGNB: multidrug-resistant Gram-negative bacilli.