Table 4.
Kinetic models of Doxy Hyc release from studied mucoadhesive buccal films (F1–F3, according to Table 1).
| Kinetic Models | Parameters | Formulation | ||
|---|---|---|---|---|
| F1 | F2 | F3 | ||
| Zero—order model | R2 | 0.6193 | 0.5998 | 0.7412 |
| K0 | 2.76 | 2.53 | 2.94 | |
| First—order model | R2 | 0.9278 | 0.8799 | 0.9908 |
| K1 | 0.134 | 0.109 | 0.178 | |
| Higuchi model | R2 | 0.8434 | 0.8261 | 0.9212 |
| KH | 16.83 | 15.46 | 17.05 | |
| Korsmeyer-Peppas model | R2 | 0.9589 | 0.9532 | 0.9792 |
| KHP | 44.67 | 46.65 | 43.90 | |
| n | 0.303 | 0.275 | 0.286 | |
Where, R2 represents the correlation coefficients. The k0, k1, kH, kHP, are rate constants following the zero-order, first-order, Higuchi and Korsmeyer–Peppas mathematical models, respectively. The n was the release exponent. The data fitting are presented in Supplementary Materials, Figure S1a,b.