Fig. 4.
Competition-induced release observed in a pore where explicit FG nups are replaced by an implicit potential. (A) Flux through the pore (normalized by its value at an NTR concentration of 1 μM) does not saturate. Inset: Flux plotted on linear axes. (B) Translocation probabilities and transport times both decrease as crowding within the pore increases. Error bars indicate SE. (C) Effective potentials measured from simulations. Crowding reduces the depth of the effective potential. Black line: The spatially varying effective potential experienced by an NTR in the absence of crowding (SI Appendix, Text for explanation). (D) While Npore, the average number of NTRs within the pore saturates (red line), Eq. 7, the flux does not due to a crowding-induced increase in the escape rates (blue line); SI Appendix, Text for discussion.