Skip to main content
. 2023 Feb 1;120(6):e2212864120. doi: 10.1073/pnas.2212864120

Fig. 8.

Fig. 8.

Model of hsa_circ_0001400 in virus-host interactions. (A) Proposed model of circ_0001400’s regulation of PI3K/AKT/mTOR pathway. (B) hsa_circ_0001400 is induced by multiple herpesviruses. The circRNA allows activation of PI3K/AKT/mTOR pathway and promotes cell growth of latently KSHV-infected cells. On the other hand, lytic infection is suppressed by inhibition of virus production and increase of co-stimulatory molecules by circ_0001400.