Changes in lipid fingerprint due to exposure to Cannabis sativa plant extracts, expressed as percentage of relative intensity of each extract with respect to the control. (A) Glycerophospholipids (PC, PC-O, PC-P, and PA). (B) Sphingolipids and glycerophospholipids (SM, CerP, PE, PE-O, PE-P, PI, and Lyso-PIP2). Normality was tested for each lipid species separately by Bartlett test; α was set at 0.05. Student t-test or Wilcoxon test were performed on the parametric or non-parametric samples, respectively. The tests were two-tailed; α was set at 0.05. p-value < 0.05 (*); <0.01 (**); <0.001 (***); and <0.0001 (****). Black arrows indicate the absence of a lipid species in this sample. Abbreviations: glycerophosphocholine, ether and plasmalogen forms—PC, PC-O, and PC-P); glycerophosphatidic acid—PA; sphingomyelin—SM; ceramide phosphate—CerP; glycerophosphoethanolamine, ether form and plasmalogen form—PE, PE-O, and PE-P; glycerophosphatidilinositol—PI; and lysophosphoinositol bisphosphate—Lyso-PIP2.