Fig. 7.

Schematic diagram showing that Cpeb1b modulates HSPCs development via cytoplasmic polyadenylation of shha mRNA. Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA is important for enhancing its translation efficiency and therefore increases the Shha protein level. An increase in the number of Shha protein is required for definitive hematopoiesis by regulating Hedgehog–Vegf–Notch signaling axis. In the absence of Cpeb1b, the Shha protein level is reduced, which results in downregulation of Hedgehog–Vegf–Notch signaling axis, further leading to definitive hematopoiesis defect.