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. 2023 Feb 17;16(2):315. doi: 10.3390/ph16020315

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Imaging and treatment of prostate cancer in mouse models using PSMA-targeted liposome-like texaphyrin NPs. (A) Synthetic scheme showing chelation of lutetium with texaphyrin−lipid. (B) Formulation and representation of nanotexaphyrin self-assembly. (C) Radiolabeling conditions and schematic representation of ¹¹¹In/Lu-labelled nanotexaphyrin. (D) Schematic representation of PSMA-targeting ligand (ACUPA) conjugated ¹¹¹In/Lu–nanotexaphyrin. (E) mSPECT/CT images of a mouse model bearing dual xenografts of PC3-Pip and PC3-Flu. Reprinted with permission from Ref [61]. Copyright 2022, American Chemical Society.