Figure 14.

Development of PSMA-targeted starPEG nanocarriers for prostate cancer imaging. (A) Representative chemical structures of ⁸⁹Zr-labelled PEG nanocarriers without and with different numbers of PSMA-targeting ACUPA ligands. (B) Maximum intensity projection (MIP) μPET/CT, axial μPET/CT, and axial CT images obtained at 216 h following administration of ⁸⁹Zr-labelled nanocarriers in mice model bearing PC3-Pip and PC3-Flu dual xenografts. (C) Autoradiography images of tumor slices were collected after 216 h post-injection of the ⁸⁹Zr-labelled nanocarriers. Reprinted with permission from Ref [69]. Copyright 2022, American Chemical Society.