Table 3.

Overview of the most relevant lncRNAs in OA.

lncRNA	Expression in OA	Effective Role	Species	References
CRNDE	↑	↑ Upregulated in knee OA	Human	[154]
HOTAIR	↑	↑ Apoptosis, ↓ autophagy by targeting miR-130-3p	Human	[157]
		Inhibits proliferation of IL-1β-induced chondrocytes ↑ Apoptosis and ECM degradation by targeting miR-20b	Mouse	[158]
		↑ Apoptosis	Human	[159]
ILF-AS1	↓	↑ Downregulated in knee OA	Human	[154]
KCNQ1OT1	↓	↑ Viability, ↓ Apoptosis, inflammation, and ECM catabolism ↑ PIK3C2A and activated the PI3K/AKT/ mTOR pathway by targeting miR-218-5p	Human	[138]
LINC01089	↓	↑ Downregulated in knee OA	Human	[154]
LINC01139	↑	↑ Upregulated in hip OA	Human	[154]
LINC01614	↑	↑ Upregulated in knee OA	Human	[154]
LINC01679	↓	↑ Downregulated in hip OA	Human	[154]
LUCAT1	↓	↑ Downregulated in hip OA	Human	[154]
MALAT1	↓	Blocks the activation of JNK signalling pathway ↓ Col II, ↑ Mmp-13 in IL-1β-induced chondrocytes	Rat	[160]
	↑	↓ Col II, ↑ Mmp-13, Cox-2, Il-6 by targeting miR-146a in LPS-induced chondrocytes	Rat	[161]
MEG3	↓	↑ Downregulated in hip OA	Human	[154]
		↑ Downregulated in knee OA
MIR22HG	↑	↑ Upregulated in knee OA	Human	[154]
NORAD	↑	↑ Upregulated in hip OA	Human	[154]
PACER	↓	Inhibits HOTAIR and apoptosis in CHON-001	Human	[159]
PART1	↑	↑ Upregulated in hip OA	Human	[154]