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. 2023 Jan 26;15(2):415. doi: 10.3390/pharmaceutics15020415

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histological photomicrographs of liver tissue (stained with H&E, unless mentioned otherwise, 200×). (a) Sections from normal mice (GI) showing a normal architecture of hepatic lobules. (b) Sections from infected mice (GII) displaying moderate degeneration of hepatocytes (black arrow) and focal infiltration with mononuclear cells (red arrow). (c) Sections from infected mice (GIII) treated with the reference drug, NTZ, displayed mild degeneration of hepatocytes. (d) Sections from infected mice (GIV) treated with H. hemistemon extract (100 mg/kg) showed moderate hepatocellular degeneration (black arrow) and focal infiltration by mononuclear cells (red arrow). (e) Sections from infected mice (GIV) treated with H. hemistemon extract (200 mg/kg) showed a retained hepatic lobular architecture.