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Structural similarity of β-sitosterol with estradiol and potential anti-influenza activity. (a) Chemical structure of the potent human estrogen form; namely estradiol; (b) the cytotoxicity of estradiol as expressed in CC50 and the antiviral activity against A/H1N1 as expressed as an IC50 value. GraphPad Prism 5.01 software was used to analyze the nonlinear regression, while the CC50 and IC50 were determined by plotting log inhibitor against normalized response (variable slope).
