Table 2.
Selectivity indices for the screened compounds against influenza A/H1N1 and A/H5N1 subtypes.
| Compound | Virus | CC50 (mg/mL) | IC50 (mg/mL) | SI |
|---|---|---|---|---|
| Silybin | H1N1 | 9.48 | N/A | ND |
| H5N1 | N/A | ND | ||
| 7-Hydroxy flavone | H1N1 | 5.83 | 0.360 | 16.194 |
| H5N1 | N/A | ND | ||
| Naringin | H1N1 | >10 | 0.0206 | >485.43 |
| H5N1 | N/A | ND | ||
| Pinocembrin | H1N1 | >10 | >10 | >1 |
| H5N1 | N/A | ND | ||
| Kaempferitrin | H1N1 | >10 | 0.0478 | >209.20 |
| H5N1 | N/A | ND | ||
| Flavanone | H1N1 | 0.45 | N/A | ND |
| H5N1 | N/A | ND | ||
| Isoquercitrin | H1N1 | 0.71 | 0.167 | 4.25 |
| H5N1 | N/A | ND | ||
| Saponin | H1N1 | >10 | 0.326 | >30.674 |
| H5N1 | N/A | ND | ||
| Lupeol | H1N1 | 0.56 | 0.0936 | 5.98 |
| H5N1 | N/A | ND | ||
| D-Glucuronic acid | H1N1 | 10.26 | N/A | ND |
| H5N1 | N/A | ND | ||
| D-Galacturonic acid | H1N1 | 9.61 | N/A | ND |
| H5N1 | N/A | ND | ||
| β-sitosterol | H1N1 | 9.9 | 0.000975 | 10,154 |
| H5N1 | 0.000295 | 33,559 | ||
| β-sitosterol-O-glucoside | H1N1 | 1.75 | 0.000719 | 2434 |
| H5N1 | 0.000613 | 2855 | ||
| Ouabain | H1N1 | 0.176 | N/A | ND |
| H5N1 | N/A | ND | ||
| Digitonin | H1N1 | 0.442 | 0.0215 | 20.56 |
| H5N1 | N/A | ND | ||
| Chrysophanic acid | H1N1 | 0.0461 | N/A | ND |
| H5N1 | N/A | ND | ||
| Aloe emodin | H1N1 | 2.28 | 0.729 | 3.127 |
| H5N1 | N/A | ND | ||
| Arbutin | H1N1 | >10 | 0.764 | >13.09 |
| H5N1 | N/A | ND | ||
| O-Coumaric acid | H1N1 | 9.172 | NA | ND |
| H5N1 | N/A | ND | ||
| Vanillin | H1N1 | 0.242 | N/A | ND |
| H5N1 | N/A | ND | ||
| D-sorbitol | H1N1 | >10 | 3.11 | >3.215 |
| H5N1 | N/A | ND | ||
| D-(-) salicin | H1N1 | >10 | N/A | ND |
| H5N1 | N/A | ND | ||
| Zanamivir | H1N1 | >10 | 0.000792 | >12,626 |
| H5N1 | 0.000265 | >37,736 |
CC50: half-maximal cytotoxic concentration; IC50: half-maximal inhibitory concentration; SI: selectivity index = CC50/IC50.