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. 2023 Feb 8;13(2):470. doi: 10.3390/life13020470

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TMZ-only, OLE-only, and OLE phenolics dose-dependently decreased GB cell proliferation. A WST-1 test detected the IC50 dose of TMZ-only (A,B), OLE-only (C,D), OL-only (E,F), HT-only (G,H), TYR-only (I,J), and rutin-only (K,L). A total of 2 × 10⁴ T98G and A172 cells were positioned to 96-well transparent plates and exposed to the tested agents dose-dependently for 24 h. WST-1 activity was recorded at 450 nm absorbance after 2 h of exposure. p-values were calculated using one-way ANOVA and Tukey’s post hoc tests (n = 3). Data are presented as mean ± SD. * p < 0.05; ** p < 0.0001 versus untreated cells. UNT: untreated, TMZ: temozolomide, OLE: Olea europaea leaf extract, OL: oleuropein, HT: hydroxytyrosol, TYR: tyrosol.