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. 2023 Feb 13;24(4):3709. doi: 10.3390/ijms24043709

Figure 2.

Figure 2

6-OHDA and FAC decrease cell viability and induce LRRK2 activation. SH-SY5Y cells were treated with 100 μM of 6-OHDA or 5 μg/mL of FAC for 24 h. (A) Cell viability by MTT assay (n = 12). (B) Cell viability by LDH assay. After 6-OHDA and FAC treatment, the cellular medium was collected and analyzed by LDH assay (n = 10). (C) The level of pS935-LRRK2. (D) The level of pS1292-LRRK2. Upper: representative Western blot images of pS935-LRRK2 or pS1292-LRRK2, lower: quantification of the levels of pS935-LRRK2 or pS1292-LRRK2 in SH-SY5Y cells (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001.