Table 3.
Basic information and allele frequencies of the 28 selected SNPs.
| SNP (Gene Name) | Pathway | Chr * | Positions ** | Allele | Minor Allele Frequency | |
|---|---|---|---|---|---|---|
| Case | Control | |||||
| rs25487 (XRCC1) | BER | 19 | 43551574 | C/T | 0.34 | 0.38 |
| rs3218536 (XRCC2) | DSB | 7 | 152648922 | C/T | 0.48 | 0.49 |
| rs1052133 (OGG1) | BER | 3 | 9757089 | C/G | 0.29 | 0.26 |
| rs246079 (UNG) | BER | 12 | 109109255 | A/G | 0.5 | 0.47 |
| rs151095402 (UNG) | BER | 12 | 109098561 | C/T | 0.01 | 0.02 |
| rs1801320 (RAD51) | HR | 15 | 40695330 | G/C | 0.3 | 0.24 |
| rs7180135 (RAD51) | HR | 15 | 40731896 | A/G | 0.48 | 0.36 |
| rs1801321 (RAD51) | HR | 15 | 40695367 | G/T | 0.26 | 0.48 |
| rs2619681 (RAD51) | HR | 15 | 40696823 | C/T | 0.18 | 0.22 |
| rs963917 (RAD51B) | HR | 14 | 68595606 | A/G | 0.28 | 0.44 |
| rs963918 (RAD51B) | HR | 14 | 68595397 | C/T | 0.46 | 0.31 |
| rs3784099 (RAD51B) | HR | 14 | 68283210 | A/G | 0.27 | 0.28 |
| rs10483813 (RAD51B) | HR | 14 | 68564567 | A/T | 0.2 | 0.22 |
| rs3087404 (SMUG1) | BER | 12 | 54187830 | T/C | 0.42 | 0.48 |
| rs1042522 (TP53) | BER/DSB | 17 | 7676154 | C/G | 0.28 | 0.33 |
| rs1051669 (RAD52) | DSB | 12 | 913286 | C/T | 0.2 | 0.21 |
| rs2307293 (MBD4) | BER | 3 | 129431542 | C/G | 0.02 | 0.02 |
| rs3219472 (MUTYH) | BER | 1 | 45338378 | C/T | 0.19 | 0.19 |
| rs3219489 (MUTYH) | BER | 1 | 45331833 | C/G | 0.23 | 0.22 |
| rs3219493 (MUTYH) | BER | 1 | 45330597 | C/G | 0.08 | 0.08 |
| rs2155209 (MRE11A) | DSB | 11 | 94417624 | C/T | 0.37 | 0.42 |
| rs2735383 (NBS1) | DSB | 8 | 89935041 | C/G | 0.3 | 0.34 |
| rs132774 (XRCC6) | NHEJ | 22 | 41635949 | C/G | 0.48 | 0.44 |
| rs207906 (XRCC5) | NHEJ | 2 | 216148178 | A/G | 0.31 | 0.2 |
| rs7003908 (PRKDC) | NHEJ | 8 | 47858141 | A/C | 0.46 | 0.48 |
| rs4135054 (TDG) | BER | 12 | 103969832 | C/T | 0.1 | 0.14 |
| rs1776180 (EXO1) | MMR | 1 | 241848042 | C/G | 0.44 | 0.49 |
| rs861539 (XRCC3) | HR | 14 | 103699416 | A/G | 0.16 | 0.26 |
* Chromosome; ** Chromosome position according to the Genome Reference Consortium Human Build 38; BER: Base Excision Repair; MMR: Mismatch Repair; DSB Repair: Double Strand Break Repair; NHEJ: nonhomologous DNA end joining; HR: homologous recombination.