4EBP1 |
eukaryotic translation initiation factor 4E-binding protein 1 |
ACT1 |
NF-κB activator 1 |
Akt |
protein kinase B |
ANGPTL4 |
angiopoietin-like 4 |
AP-1 |
activating protein-1 |
APC |
antigen-presenting cell |
ART |
adipose-resident T cells |
ASK1 |
apoptosis signaling kinase 1 |
bFGF |
basic fibroblast growth factor |
BSF-2 |
B-cell stimulating factor-2 |
CAFs |
cancer-associated fibroblasts |
CASP1 |
caspase 1 |
CCL |
C-C motif ligand |
CLS |
crown-like structures |
COX2 |
cyclo-oxygenase-2 |
CSFs |
colony-stimulating factors |
CXCL |
C-X-C motif ligand |
DCs |
dendritic cells |
EGF |
epidermal growth factor |
ELK |
E26 transformation-specific like-1 protein |
EMT |
epithelial-to-mesenchymal transition |
ERK |
extracellular signal-regulated kinase |
FADD |
Fas-associated protein with death domain |
FAK |
focal adhesion kinase |
FXR |
farnesoid X receptor |
γδT |
γδT lymphocytes |
GAB1/2 |
GRB2-associated-binding protein 1 or 2 |
GRB2 |
growth factor receptor-bound protein 2 |
HIF-1α |
hypoxia-inducible factor-1α |
IFNγ |
interferon-γ |
IKK-β |
inhibitor of nuclear factor kappa-B kinase subunit beta |
IL |
interleukin |
IL-1β |
interleukin-1β |
IL-6 |
interleukin-6 |
IL-6R |
IL-6 receptor |
IL-8 |
interleukin-8 |
IL-10 |
interleukin-10 |
iNOS |
inductible nitric oxide synthase |
IRAK |
interleukin-1 receptor-associated kinase |
IRF4 |
interferon regulatory factor 4 |
IRS |
insulin receptor substrate |
JAK |
Janus kinase |
JNK |
c-Jun N-terminal kinase |
LPS |
lipopolysaccharides |
MAPK |
mitogen-activated-protein kinase |
MCP-1 |
monocyte chemoattractant protein-1 |
MDSC |
myeloid-derived suppressor cells |
MEKK |
mitogen-activated protein kinase kinase |
MEK/MKK |
mitogen-activated protein kinase kinase |
MHC |
major histocompatibility complex |
MMP |
matrix metallopeptidase |
mTOR |
mammalian target of rapamycin |
MYC |
myelocytomatosis oncogene |
MYD88 |
myeloid differentiation primary response 88 |
NFAT |
nuclear factor associated with activated T cells |
NF-κB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
NK |
natural killer |
NKT |
natural killer T |
ObR |
leptin receptor |
PDK1 |
phosphoinositide-dependent kinase-1 |
PTB |
phosphotyrosine-binding domains |
PI3K |
phosphatidylinositol 3-kinase |
PIP3 |
phosphatidylinositol-3,4,5-trisphosphate |
PKC |
protein kinase C |
PLC |
phospholipase C |
RAF |
rapidly accelerated fibrosarcoma |
RANKL |
receptor activator of nuclear factor kappa-B ligand |
RAS |
rat sarcoma virus |
RIP |
ribosome-inactivating protein |
RORγt |
RAR-related orphan nuclear receptor-γt |
ROS |
reactive oxygen species |
SHC |
SHC (Src homology 2 domain containing) transforming protein |
SHP2 |
Src homology region 2-containing protein tyrosine phosphatase |
SOCS3 |
suppressor of cytokine signaling 3 |
SOS |
son of sevenless |
SRC |
proto-oncogene, non-receptor tyrosine kinase |
STAT |
signal transducer and activator of transcription |
TAB |
mitogen-activated protein kinase kinase kinase 7-interacting protein |
TAK |
mitogen-activated protein kinase kinase kinase 7 |
TAMs |
tumor-associated macrophages |
TANs |
tumor-associated neutrophils |
TGF-β |
transforming growth factor-β |
Th1 |
T-helper 1 |
Th2 |
T-helper 2 |
Th17 |
T-helper 17 |
Tregs |
regulatory T cells |
TLRs |
toll-like receptors |
TME |
tumor micro-environment |
TNFα |
tumor necrosis factor-α |
TNFR |
tumor necrosis factor-α receptor |
TRADD |
tumor necrosis factor receptor type 1-associated DEATH domain protein |
TRAF |
tumor necrosis factor receptor-associated factors |
TYK |
tyrosine kinase |
VEGF |
vascular endothelial growth factor |