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Shows how alterations in pancreatic α-cells, including melatonin production and its upregulation of the cystine-glutamate antiporter (system χc), may act to upregulate NAS in pancreatic β-cells via mGluR5 activation, thereby increasing trophic and survival processes in pancreatic β-cells. Abbreviations: AMPA: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; mGluR5: metabotropic glutamate receptor 5; NAS: N-acetylserotonin; TrkB: tyrosine kinase receptor B.
