Table 6.

Top differentially methylated CpGs for the epigenome-wide methylation analysis of tobacco smoking status (5 levels) ¹, in men and women, after multivariate adjustment ².

Men (n = 186)					Women (n = 228)
CpG Site	Gene Symbol	Chr	p	r	CpG Site	Gene Symbol	Chr	p	r
cg21566642		2	2.20 × 10−15	−0.561	cg21566642		2	4.07 × 10−16	−0.522
cg03636183	F2RL3	19	1.92 × 10−11	−0.487	cg14391737	PRSS23	11	2.51 × 10−12	−0.458
cg01940273		2	3.73 × 10−10	−0.458	cg05575921	AHRR	5	1.55 × 10−11	−0.443
cg17287155	AHRR	5	8.37 × 10−9	−0.425	cg09935388	GFI1	1	5.80 × 10−11	−0.431
cg17739917	RARA	17	1.28 × 10−8	−0.420	cg17739917	RARA	17	1.32 × 10−10	−0.424
cg14391737	PRSS23	11	3.89 × 10−8	−0.407	cg00475490	PRSS23	11	2.57 × 10−10	−0.418
cg19572487	RARA	17	9.96 × 10−8	−0.396	cg01940273		2	8.28 × 10−10	−0.407
cg04551776	AHRR	5	1.37 × 10−7	−0.392	cg21911711	F2RL3	19	9.46 × 10−10	−0.405
cg15342087		6	1.48 × 10−7	−0.391	cg24859433		6	1.94 × 10−9	−0.398
cg27241845		2	1.56 × 10−7	−0.390	cg25966498	SPATA17	1	9.11 × 10−9	−0.383
cg21911711	F2RL3	19	2.96 × 10−7	−0.382	cg18110140		15	1.08 × 10−8	−0.381
cg18110140		15	1.25 × 10−6	−0.363	cg11556164	LRRN3	7	1.65 × 10−8	−0.376
cg23161492	ANPEP	15	1.28 × 10−6	−0.362	cg19572487	RARA	17	2.51 × 10−8	−0.372
cg24090911	AHRR	5	1.32 × 10−6	−0.362	cg25648203	AHRR	5	6.15 × 10−8	−0.362
cg24859433		6	2.12 × 10−6	−0.355	cg25189904	GNG12	1	7.29 × 10−8	−0.360
cg01901332	ARRB1	11	3.67 × 10−6	−0.348	cg21929649	EFTUD2	17	2.90 × 10−7	−0.344

¹ Five levels of smoking status were considered as an ordinal variable: Never smoker, former smoker, smoker > 5 years, former smoker 1 to 5 years, former smoker < 1 year, and current smoker. ² Models were adjusted for age, diabetes, body mass index, batch effect, leukocyte cell-types and stratified by sex (n = 186 in men and n = 228 in women). Chr: chromosome; p: Multivariate adjusted p-values; r: partial correlation coefficient.