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. 2023 Feb 13;15(2):631. doi: 10.3390/pharmaceutics15020631

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characterization of PCLP-CUR. (A) Morphologies observed by transmission electron microscopy (upper panel) and size distributions observed by a Zetasizer (bottom panel). (B) Stability of PCLP-CUR at 4 °C for 10 days in terms of relative encapsulation efficiency. (C) Zeta potentials of various nanoparticles observed by a Zetasizer. (D) Fluorescence images of PCLP observed by confocal laser scanning microscopy. The PNV and CLP were labeled with DiO (green) and DiD (red), respectively. Yellow color indicated a colocalization between the two corresponding signal. (E) The results of SDS-PAGE analysis. (F) Western blot analysis of key platelet membrane proteins. (G) Drug release characteristics of PCLP-CUR at pH 5.0, 6.5 or 7.4. (H) Drug release characteristics of PLP-CUR at pH 5.0, 6.5 or 7.4.