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Pharmacokinetics of PCLP-CUR. (A) Plasma drug concentrations versus time profiles after intravenous injection of various formulations in rats (n = 5). (B) AUC, (C) MRT, (D) Cl values of CUR, LP-CUR and PCLP-CUR (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. AUC: area under the plasma concentration-time curve; Cl: clearance rate; MRT: mean residence time.
