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In vivo tumor targeting capability of PCLP observed by a multimodal animal imaging system. (A) In vivo fluorescent imaging of HepG2 tumor bearing mice at 6, 10, 24 and 32 h after intravenous injection of PCLP-DiR and LP-DiR. (B) Ex vivo fluorescent imaging of the excised tumors and organs at 24 h post injection of PCLP-DiR and LP-DiR. (C) Region-of-interest analysis of fluorescence intensities from the tumors and organs (n = 3). * p < 0.05.
