Table 1.
Influenza VLP vaccines and their clinical trials.
| Target | Antigens and Virus Strain | Responsible Party | Clinical Trial Phase and Identifier |
|---|---|---|---|
| Avian | HA (A/Indonesia/05/05, H5N1) | IDRI | Phase 1 NCT01657929 |
| Avian | HA (A/Indonesia/05/05, H5N1) | Novavax | Phase 1/2 NCT00519389, NCT01594320, NCT01596725 |
| Avian | H7N9 (A/Anhui/1/13) | Novavax | Phase 1/2 NCT01897701, NCT02078674 |
| Avian | HA (A/Indonesia/05/05, H5N1) | Medicago | Phase 2 NCT01991561 |
| Avian | HA (A/Hanzhou/1/13, H7N9) | Medicago | Phase 1 NCT02022163 |
| Trivalent Seasonal |
HA (A/Brisbane/59/07, H1N1) HA (A/Brisbane/10/07, H3N2) HA (B/Brisbane/60/08, Victoria) |
Novavax | Phase 2 NCT01014806 |
| Quadrivalent Seasonal |
HA (A/Brisbane, H1N1) HA (A/Kansas, H3N2) HA (B/Maryland, Victoria) HA (B/Phuket, Yamagata) |
Novavax | Phase 3 NCT04120194 |
| Quadrivalent Seasonal |
HA (A/California/07/09, H1N1) HA (A/Victoria/361/11, H3N2) HA (B/Brisbane/60/08, Victoria) HA (B/Massachusetts/02/12, Yamagata) |
Medicago | Phase 3 NCT03301051, NCT03321968, NCT03739112 |
| Pandemic | HA (A/California/07/09, H1N1) | Novavax | Phase 2 NCT01072799 |
| Universal | H1-Ferritin HA (A/New Caledonia/20/1999, H1N1) |
National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 NCT03814720 |
| Universal | H2-Ferritin HA (A/Singapore/1/1957, H2N2) |
National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 NCT03186781 |
| Universal | H10-Ferritin HA (A/Jianxi/IPB13/2013, H10N8) |
National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 NCT04579250 |