. 2023 Feb 16;16(2):310. doi: 10.3390/ph16020310

Table 1.

General conditions for the synthesis of the series 1 (compounds 11–22).

Compound	X₅	Isocyanide	Acid	Time (h)	Yield (%) ^a,b,c
11	H	tert-butyl	ClCH₂COOH	48	65
12	I	tert-butyl	ClCH₂COOH	72	28
13	NO₂	tert-butyl	ClCH₂COOH	72	52
14	Cl (Cl = X₇)	tert-butyl	ClCH₂COOH	72	30
15	Br	Cyclohexyl	CF₃COOH	48	58
16	Br	tert-butyl	ClCH₂COOH	72	21
17	I	tert-butyl	CF₃COOH	48	60
18	I	Cyclohexyl	CF₃COOH	48	55
19	Br	tert-butyl	CF₃COOH	48	58
20	NO₂	tert-butyl	CF₃COOH	48	55
21	NO₂	Cyclohexyl	CF₃COOH	48	57
22	Br	Cyclohexyl	ClCH₂COOH	72	42

^a Yield after purification. ^b All reactions used n-butylamine as the amino component, molecular sieves 3Å, rt. ^c All reactions were treated with Capsule@Amberlyst-15 for isocyanide scavenging.