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. 2023 Feb 3;15(2):429. doi: 10.3390/v15020429

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EBV miRNA: Function of Epstein–Barr virus (EBV)-derived miRNAs in the modulation of host signaling pathway and immune evasion. EBV-derived miRNAs downregulate the gene expression of host proteins involved in the process of apoptosis to restrict programmed cell death, tumor suppressor genes to initiate cellular replication, and proinflammatory cytokines to deregulate the pattern recognition receptors. EBV-derived miRNAs also restrict the expression of viral oncoprotein (LMP1) and inhibit viral LMP2A protein synthesis to escape immune recognition.