Table 1.
HIV-1 gene associated with antiviral resistance when using the DeepChek® Assay Whole Genome HIV-1 Genotyping.
| Anti-HIV Drug Class | HIV-1 Gene Target | Target-Specific Assay (Fragment#) | Whole-Genome Assay (Fragment#) |
|---|---|---|---|
| Capsid inhibitors | gag | - | 1 |
| Nucleoside reverse transcriptase inhibitors (NRTIs) | reverse transcriptase | 1 | 2 |
| Non-nucleoside reverse transcriptase inhibitors (NNRTIs) | reverse transcriptase | 1 | 2 |
| Protease inhibitors (PIs) | protease | 2 | 2 |
| Integrase inhibitors (IIs) | integrase | 3 | 2 |
| Integrase strand transfer inhibitors (INSTIs) | integrase | 3 | 2 |
| n.a. | vif, vpr, vpu (accessory proteins) | - | 3 |
| Fusion inhibitors | gp41 | - | 4 |
| Post-attachment inhibitors | gp120 | - | 4 |
| n.a. | nef (accessory protein) | - | 5 |