Table 4.
Genes from significant KEGG pathways coding for differential hepatic expression of proteins in SHR-CRP rats treated with beetroot juice versus SHR-CRP untreated controls.
| KEGG Pathway | Counts | p-Value | Benjamini |
|---|---|---|---|
| Metabolic pathways | 65 | 3.0 × 10−19 | 6.2 × 10−17 |
| ↑Aox1, ↑Aox3, ↑Akr1d1, ↑Amdhd1, ↑Aoc3, ↑Car14, ↑Cept1, ↑Cyp2a1, ↑Cyp2a2, ↑Cyp2c13, ↑Cyp2c7, ↑Cyp4a2, ↑Cox6a1, ↑Cox6b1, ↑Dpys, ↑Ephx2, ↑Etnk2, ↑Flad1, ↑Fmo5, ↑Fcsk, ↑Ggt5, ↑Gne, ↑Gsta2, ↑Gsta5, ↑Gstm3, ↑Gstm4, ↑Hykk, ↓Hsd17b2, ↓Ido2, ↓Inmt, ↓Impa2, ↑Lpin1, ↑Mat2a, ↓Mocs2, ↑Nnmt, ↑Naprt, ↑Pemt, ↑Pde8a, ↓Plod1, ↑Prodh2, ↑Rdh5, ↓Sptlc2, ↑Srd5a1, ↑Sdhd, ↑Tat, ↑Urad, ↑Vnn3 | |||
| Retinol metabolism | 14 | 7.1 × 10−11 | 7.4 × 10−9 |
| ↑Ugt1a7, ↑Adh1, ↑Adh4, ↑Aldh1a1, ↑Aldh1a7, ↑Aox1, ↑Aox3, ↑Cyp2a1, ↑Cyp2a2, ↑Cyp2c13, ↑Cyp2c7, ↑Cyp4a2 | |||
| Steroid hormone biosynthesis | 8 | 1.0 × 10−4 | 3.6 × 10−3 |
| ↑Ugt1a7, ↑Akr1d1, ↑Cyp2c13, ↑Cyp2c7, ↑Cyp2d3, ↓Hsd17b2, ↑Srd5a1 | |||
| Tyrosine metabolism | 6 | 1.3 × 10−4 | 3.8 × 10−3 |
| ↑Adh1, ↑Adh4, ↑Aox1, ↑Aox3, ↑Aoc3, ↑Tat | |||
| Glycerophospholipid metabolism | 7 | 1.8 × 10−3 | 4.2 × 10−2 |
| ↑Agpat2, ↑Cept1, ↑Lpin1, ↑Pnpla6, ↓Pnpla7, ↑Pemt | |||
| Glutathione metabolism | 6 | 2.4 × 10−3 | 4.9 × 10−2 |
| ↑Ggt5, ↑Gsta2, ↑Gsta5, ↑Gstm3, ↑Gstm4 | |||
↑ denotes upregulated hepatic protein expression in SHR-CRP rats treated with beetroot versus untreated controls; ↓ denotes downregulated hepatic protein expression in SHR-CRP rats treated with beetroot versus untreated controls.