Table 3.
Distribution of the GSTP1 A>G (rs1695) genotypes and alleles in the overall study population according to the prevalence of somatosensory signs (Sawré Muybu indigenous territory, Pará State, Brazilian Amazon, 2019).
| GSTP1 (rs1695) A>G 1 | ||||
|---|---|---|---|---|
| Somatosensory Signs | AA | AG | GG | p-Value 2 |
| Distal pinprick perception | ||||
| Normal | 37 (45.7) | 33 (40.7) | 11 (13.6) | 0.15 |
| Abnormal | 6 (24.0) | 15 (60.0) | 4 (16.0) | |
| ORc (95% IC) | 1 | 2.80 (0.97–8.06) | 2.24 (0.54–9.40) | |
| ORa 3 (95% IC) | 1 | 3.16 (1.07–9.31) | 1.81 (0.39–8.43) | |
| Distal thermal sensitivity | ||||
| Normal | 37 (42.0) | 38 (43.2) | 13 (14.8) | 0.63 |
| Abnormal | 6 (33.3) | 10 (55.6) | 2 (11.1) | |
| ORc (95% IC) | 1 | 1.62 (0.54–4.92) | 0.95 (0.17–5.30) | |
| ORa 3 (95% IC) | 1 | 1.79 (0.58–5.53) | 0.67 (0.11–4.12) | |
| Hallux or thumb vibration sensitivity | ||||
| Normal | 39 (41.1) | 44 (46.3) | 12 (12.6) | 0.41 |
| Abnormal | 4 (36.4) | 4 (36.4) | 3 (27.3) | |
| ORc (95% IC) | 1 | 0.89 (0.21–3.78) | 2.44 (0.48–12.45) | |
| ORa3 (95% IC) | 1 | 0.98 (0.22–4.37) | 1.84 (0.29–11.84) | |
| Feet mechanical detection threshold | ||||
| Normal | 39 (42.9) | 39 (42.9) | 13 (14.3) | 0.43 |
| Abnormal | 4 (26.7) | 9 (60.0) | 2 (13.3) | |
| ORc (95% IC) | 1 | 2.25 (0.64–7.92) | 1.50 (0.25–9.16) | |
| ORa 3 (95% IC) | 1 | 2.50 (0.70–9.00) | 1.05 (0.15–7.18) | |
| Clinical signs of polyneuropathy 4 | ||||
| No | 34 (48.6) | 26 (37.1) | 10 (14.3) | 0.04 |
| Yes | 9 (25.0) | 22 (61.1) | 5 (13.9) | |
| ORc (95% IC) | 1 | 3.20 (1.26–8.09) | 1.89 (0.51–6.94) | |
| ORa 3 (95% IC) | 1 | 3.67 (1.42–9.53) | 1.41 (0.35–5.68) | |
ORc = crude odds ratio. 1 Missing information from 1 individual. 2 p-value obtained from the χ2 test (Pearson p-value) or Fisher’s exact test, when needed. 3 Odds ratio adjusted (ORa) for age and Hg exposure levels. 4 Neuropathy burden.