Table 4.
Distribution of the GSTP1 A>G (rs1695) genotypes and alleles in the overall study population according to the prevalence of motor and cognitive signs (Sawré Muybu indigenous territory, Pará State, Brazilian Amazon, 2019).
| GSTP1 (rs1695) A>G 1 | ||||
|---|---|---|---|---|
| Functions | AA | AG | GG | p-Value 2 |
| Motor | ||||
| Toe amyotrophy | ||||
| Normal | 43 (42.6) | 43 (42.6) | 15 (14.9) | 0.04 |
| Abnormal | 0 (0.0) | 5 (100.0) | 0 (0.0) | |
| ORc (95% IC) | 1 | - | - | |
| ORa 3 (95% IC) | 1 | - | - | |
| Ankle jerk reflex | ||||
| Normal | 36 (40.9) | 40 (45.5) | 12 (13.6) | 0.94 |
| Abnormal | 7 (38.9) | 8 (44.4) | 3 (16.7) | |
| ORc (95% IC) | 1 | 1.03 (0.34–3.12) | 1.29 (0.29–5.77) | |
| ORa 3 (95% IC) | 1 | 1.13 (0.36–3.52) | 0.97 (0.19–4.99) | |
| Cognitive | ||||
| BCSB 4 | ||||
| Normal | 33 (40.2) | 41 (50.0) | 8 (9.8) | 0.04 |
| Abnormal | 10 (41.7) | 7 (29.2) | 7 (29.2) | |
| ORc (95% IC) | 1 | 0.56 (0.19–1.64) | 2.89 (0.84–9.95) | |
| ORa 3 (95% IC) | 1 | 0.58 (0.20–1.73) | 3.51 (0.86–14.31) | |
| Verbal fluency test | ||||
| Normal | 29 (38.7) | 35 (46.7) | 11 (14.7) | 0.83 |
| Abnormal | 14 (45.2) | 13 (41.9) | 4 (12.9) | |
| ORc (95% IC) | 1 | 0.77 (0.31–1.89) | 0.75 (0.20–2.79) | |
| ORa 3 (95% IC) | 1 | 0.79 (0.32–1.98) | 1.05 (0.25–4.34) | |
| Stick design test | ||||
| Normal | 42 (40.4) | 47 (45.2) | 15 (14.4) | 0.84 |
| Abnormal | 1 (50.0) | 1 (50.0) | 0 (0.0) | |
| ORc (95% IC) | 1 | 0.89 (0.05–14.74) | - | |
| ORa 3 (95% IC) | 1 | 0.89 (0.05–14.87) | - | |
ORc = crude odds ratio. 1 Missing information from 1 individual. 2 p-value obtained from the χ2 test (Pearson p-value) or Fisher’s exact test, when needed. 3 Odds ratio adjusted (ORa) for age and Hg exposure levels. 4 Brief cognitive screening battery.